Glycosphingolipid antibodies in serum in patients with sciatica.

摘要: Study design Serum antibody titers against 10 different glycosphingolipids were investigated by enzyme-linked immunosorbent assay in three groups of patients: patients with acute sciatica (Group IA, radicular pain for 32 +/- 36 days, n = 68), a subgroup these 4 years later IB, 23), and undergoing lumbar discectomy because disc herniation II, 37). Objectives To investigate the immunologic response analyzing circulating autoantibodies glycosphingolipids, molecules highly expressed cells from nervous system, possible correlation such antibodies to clinical imaging findings as well subjective symptoms. Summary background data The glycosphingolipid are elevated neurologic diseases autoimmune stimulation Guillain-Barre syndrome chronic inflammatory demyelinating polyneuropathy. Methods Antiglycosphingolipid assayed microtiter method. Antibody related healthy population method that judges all positive results (positive result patient sera/pooled blood donor serum >2, at titer 1/400) indicating pathologic condition. Results Increased levels one or more detected 71% sciatica, 61% 4-year follow-up visit (eight antigens analyzed) 54% discectomy. These frequencies somewhat higher than, last group similar to, those reported generalized system disorders involvement. In patients, associated increased two examined antibodies: 3'LM1 (immunoglobulin M and/or immunoglobulin G), P 0.023, GD1a M), 0.017. Conclusion presence suggests an activation immune thus process possibly involved pathophysiology sciatica. was not limited specific target; rather, overall increase system-associated observed. encourage further studies pathophysiologic relevance responses herniation.