Penicilliosis marneffei in Thailand: report of five human cases.

摘要: The first two cases of Penicillium marneffei infection in humans were reported 1959 and 1973. There had been no additional clinical reports penicilliosis marneffei, until the five new human described this paper, from Thailand. patients, three whom died, came various parts country. Their common manifestations fever generalized lymphadenopathy, with multiple soft tissue, bone, joint pulmonary involvement. Pericarditis effusion was also seen. diagnosis established by isolating identifying a dimorphic species that produced soluble red pigment its mycelial form. histopathologic features lymph nodes bone marrow similar to those histoplasmosis capsulati. However, yeast-like tissue form P. divides fission; Histoplasma capsulatum budding. Treatment amphotericin B effective when antifungal antibiotic administered early course disease.