Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition

摘要: A major paradigm shift in the way we view initiation and progression of colorectal cancer (CRC) has occurred within last decade. For many years, malignant transformation adenomatous polyps (adenomas) was considered to be only route human colon. The other common polyp type, with serrated but non-dysplastic features (also referred as hyperplastic or metaplastic polyps) seen innocuous. However, recognition at a molecular level that some may act precursor lesions for CRCs, “serrated pathway” came age, provided an alternative mechanism development CRC, existing alongside traditional adenoma–carcinoma sequence. Molecular evidence first observed patient condition called polyposis syndrome (HPS), where multiple are present throughout Since this pivotal event, HPS served model pathway CRC development, analogous by FAP sporadic In chapter, individuals have genetic predisposition, which increases their risk developing will examined. Though lesion underlying is yet identified, its inclusion predisposition concept whose time come.