Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

摘要: Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation a number cell types. It is therefore conceivable that genistein, because its reported ability to inhibit these activities vitro, may be an inducer cellular differentiation. We investigated this possibility human promyelocytic HL-60 and erythroid K-562 leukemia cells SK-MEL-131 melanoma cells. Our results indicated dose-dependent manner, inhibited multiplication induced The maturing acquired granulocytic monocytic markers. differentiating stained positively with benzidine, which indicates production hemoglobin, marker. Following genistein treatment, formed dendrite-like structures exhibited increased tyrosinase melanin content. Experiments were designed identify molecular mechanism genistein's action. Data from our laboratory suggest isoflavone triggers pathway leads by stabilizing protein-linked DNA strand breakage. Other possible mechanisms literature are discussed.