A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli.

摘要: Three proanthocyanidin trimers possessing A-type interflavanoid linkages, epicatechin-(4β→6)-epicatechin-(4β→8, 2β→O→7)-epicatechin (4), epicatechin-(4β→8, 2β→O→7)-epicatechin-(4β→8)-epicatechin (5), and epicatechin-(4β→8)-epicatechin-(4β→8, (6), were isolated from the ripe fruits of Vaccinium macrocarpon (cranberry) prevented adherence P-fimbriated Escherichia coli isolates urinary tract to cellular surfaces containing α-Gal(1→4)β-Gal receptor sequences similar those on uroepithelial cells. The structure 4 was elucidated by a combination spectroscopic methods acid-catalyzed degradation with phloroglucinol. Also weakly active (procyanidin A2) (3) inactive monomer epicatechin (1) dimer epicatechin-(4β→8)-epicatechin B2) (2).