Role of cyclic GMP in gene regulation.

摘要: Cyclic GMP is produced in response to nitric oxide and natriuretic peptides; cGMP a key regulator of cell proliferation, differentiation, apoptosis, plays an important role many (patho)physiological processes such as synaptic plasticity, angiogenesis, inflammation, cardiac hypertrophy. The regulation gene expression by has been recognized relatively recently, but cGMP-mediated increases or decreases the mRNA >60 different genes have described, profiling just beginning contribute growing list cGMP-regulated genes. Deletion over-expression experiments mice involving components signaling pathway contributed our understanding long-term effects altered signaling, including expression. We will discuss transcriptional post-transcriptional mechanisms cGMP, review specific transcription factors RNA binding proteins targeted cGMP. Some on are indirect, through modulation other pathways, e. g. mitogen-activated protein kinase pathways. However, some can be directly attributed CREB, TFII-I c-Fos, mediated cGMP-dependent kinases. regulated context their contribution particular (patho)physiologic