The Effect of Iodine-131-Rituximab on B Cell Lymphoma In Vitro and In Vivo.

摘要: The purpose of this study was to investigate the cell specific cytotoxic effect Iodine-131 Rituximab on CD20-positive B lymphoma in vitro and Raji tumors grown vivo. labeled with Iodine -131 by iodogen method. Cultured cells or nude mice bearing were treated various concentrations Iodine-131-Rituximab alone alone. results showed that lethal found a dose-dependent manner; proliferation rate significantly lower Iodine-131-Rituximab, as compared Iodine-131or (P Tumor inhibition be greatest through intratumor injection, i.p. injection (p We conclude specifically inhibits growth tumor vivo . is promising agent for radioimmunotherapy targets lymphoma.