Potassium transport in the maturing kidney.

摘要: The distal nephron and colon are the primary sites of regulation potassium (K+) homeostasis, responsible for maintaining a zero balance in adults net positive growing infants children. Distal segments can either secrete or reabsorb K+ depending on metabolic needs organism. In healthy adult kidney, secretion predominates over absorption. Baseline occurs via apical low-conductance secretory (SK) channel, whereas maxi-K channel mediates flow-stimulated urinary secretion. retention characteristic neonatal kidney appears to be due not only absence channels but also predominance H-K-adenosine triphosphatase (ATPase), which presumably Both luminal peritubular factors regulate between Perturbation any these lead imbalance. turn, may serve as effective targets treatment both hyper-and hypokalemia. purpose this review is present an overview recent advances our understanding mechanisms transport maturing kidney.