Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV‐infected children

摘要: The vertical transmission of hepatitis C virus (HCV-VT) is a major route HCV infection in children, but the risk factors remain incompletely understood. This study analyzed role interleukin 28B (IL28B) HCV-VT and spontaneous clearance among infected infants. Between 1991 2009, 145 mothers were recruited for this study: 100 HCV-RNA+ve / human immunodeficiency negative (HIV−ve), with 128 33 HCV-RNA−ve/HCV antibody+ve, 43 children. infants tested HCV-RNA at birth regular intervals until age 6 years. IL28B (single nucleotide polymorphism rs12979860) was determined assumed when children presented two subsequent blood samples. HCV-VT-infected categorized as: (1) transient viremia posterior HCV-RNA−ve without serum-conversion; (2) persistent serum-conversion. Of 31 CC polymorphism, 19 (61%) HCV-RNA+ve, whereas 68 non-CC 56 (82%) HCV-RNA+ve. In all, 26 (20%) born to acquired infection, only 9 (7%) chronically infected. rate higher viremia. No detected women. Neither mothers' nor childrens' IL-28 status associated an increased HCV-VT. influencing viral genotype non-1 IL28B. logistic regression, child predictor HCV-clearance genotype-1. Conclusion: High maternal load predictive factor plays no HCV-VT, independently genotype-1 (HEPATOLOGY 2011;)