Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator

摘要: Neuroendocrine ensembles communicate with their remote and proximal target cells via an intermittent pattern of chemical signaling. The lack a biomathematical formulation the underlying burst-generating mechanics such pulsatile secretory systems has greatly hampered quantitative analysis physiological, pharmacological, pathological regulation amplitude frequency components seemingly randomly dispersed neuroendocrine signals. Here we present stochastic differential equation model episodic glandular signaling in which random, but structured, variations burst amplitudes superimposed on basal hormone release are combined nonstationary Poisson process responsible for timing scattered bursts. Burst and/or can be modulated by deterministic trends, e.g., circadian mean expected neurosecretory or mass. We illustrate diversity output this suggest its use extracting properties irregular biological signals relevant time series. This representation behavior combines elements inherent activity apparatus.