Comparison of the Freiburg and Charlson comorbidity indices in predicting overall survival in elderly patients with newly diagnosed multiple myeloma.

摘要: Multiple myeloma occurs primarily in elderly patients. Considering the high prevalence of comorbidities, comorbidity is an important issue for management myeloma. However, impact on clinical outcomes has not been fully investigated. We retrospectively analyzed patients with newly diagnosed Comorbidities were assessed based Charlson index (CCI) and Freiburg (FCI). The CCI a summary measure 19 comorbid conditions. FCI determined by performance status, renal impairment, lung disease. This study included 127 median age 71 years. Approximately half had additional disorders at time diagnosis, diabetes mellitus was most frequent diagnosis (18.9%). significant factors prognosis among patient-related conditions history solid cancer status (ECOG ≥ 2). score divided into 3 groups (0, 1, 2-3), 2 (2-3 ≥4). strong prognostic tool OS (P > 0.001) predicted outcome better than = 0.059). In conclusion, more useful predicting overall survival