Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.

摘要: Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow infarct expansion. This study sought to determine the effect of glyceryl trinitrate (GTN) treatment in both lissencephalic gyrencephalic pre-clinical stroke models. Merino sheep underwent middle artery occlusion (MCAO) followed by GTN or control patch administration (0.2 mg/h). Monitoring numerous physiologically relevant measures over 24 h showed that was associated decreased intracranial pressure, volume, oedema midline shift compared vehicle (p < 0.05). No significant changes pressure perfusion were observed. Using optical imaging spectroscopy laser speckle imaging, varying doses (0.69-50 µg/h) tissue oxygenation examined mice. consistent found. Additional mice undergoing MCAO (doses from 0-60 µg/h) also no improvement volume neurological score within post-stroke. significantly improved stroke-related physiological outcomes but ineffective suggests that, whilst could potentially benefit patients, further research into mechanisms action are required.