Phosphine-gold(I) compounds as anticancer agents: general description and mechanisms of action.

摘要: Gold complexes have been explored as metallodrugs with great potential applications antitumoral agents. In particular, gold-phosphine derivatives seemed quite promising since the use of antiarthritic auranofin drug (thiolate-Au-PEt3 complex) presented also biological activity against different cancer cells. So, analogues within this context and for reason, main number phosphine-gold developed goal contain thiolate ligands. Other studied such tetrahedral bis(phosphine)gold(I) phosphine-gold-halides. Very recently, phosphine-gold-alkynyl shown very interesting activities although few reports are published related to them. Their mechanism action seems be clearly that used by platinum drugs (DNA intercalating processes) recent studies point inhibition Trx reductase. Cellular uptake biodistribution well reported in original works but luminescence techniques is relatively less explored. For this, these specifically review.