Continuous thoracic epidural anesthesia improves gut mucosal microcirculation in rats with sepsis.

摘要: Microcirculatory dysfunction contributes significantly to tissue hypoxia and multiple organ failure in sepsis. Ischemia of the gut intestinal are especially relevant for evolution sepsis because mucosal barrier function may be impaired, leading translocation bacteria toxins. Because sympathetic blockade enhances perfusion under physiologic conditions, we hypothesized that thoracic epidural anesthesia (TEA) attenuate microcirculatory perturbations during The present study was designed as a prospective controlled laboratory experiment assess effects continuous TEA on microcirculation cecal ligation perforation model rats. Anesthetized Sprague-Dawley rats underwent laparotomy induce Subsequently, either bupivacaine 0.125% (n = 10) or isotonic sodium chloride solution 9) continuously infused via catheter 24 h. In addition, sham carried out eight animals. Intravital videomicroscopy then performed six ten villi ileum mucosa. capillary density measured areas encircled by perfused capillaries, is, intercapillary areas. accomplished recruitment units mucosa decreasing total (1,317 +/- 403 vs. 1,001 236 microm2) (1,937 512 1,311 678 microm2, each P < 0.05). Notably, did not impair systemic hemodynamic variables beyond changes caused itself. Therefore, represent therapeutic option treat impaired resulting from Additional studies warranted other splanchnic organs inflammation.