Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy.
作者： Athanasios Blanas , Neha M. Sahasrabudhe , Ernesto Rodríguez , Yvette van Kooyk , Sandra J. van Vliet
关键词:
摘要: Aberrant glycosylation of tumor cells is recognized as a universal hallmark cancer pathogenesis. Overexpression fucosylated epitopes, such type I (H1, Lewisa, Lewisb, and sialyl Lewisa) II (H2, Lewisx, Lewisy, Lewisx) Lewis antigens, frequently occurs on the cell surface mainly attributed to upregulated expression pertinent fucosyltransferases (FUTs). Nevertheless, impact fucose-containing moieties biology not fully elucidated yet. Here, we review relevance tumor-overexpressed FUTs their respective synthesized determinants in critical aspects associated with progression, increased survival proliferation, tissue invasion metastasis, epithelial [corrected] mesenchymal transition, endothelial immune interaction, angiogenesis, multidrug resistance, stemness. Furthermore, discuss potential use enhanced levels fucosylation glycan biomarkers for early prognosis, diagnosis, disease monitoring patients.
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