The genetic epidemiology of second primary breast cancer

摘要: It is well established that women with a family history of breast cancer run higher risk than do without history. The evidence, however, less clear regarding possible association between and second primaries. purpose this prospective study was to estimate the for primary associated having breast, endometrial, ovarian cancers. A cohort 4,660 first diagnosed 1980 1982 were interviewed as part Cancer Steroid Hormone Study, multi-center population-based case-control study, followed through eight Surveillance, Epidemiology, End Results (SEER) program registries 4 6 years. Of these women, 136 developed in contralateral at least months after diagnosis primary. Cox proportional hazards modeling techniques used model time onset while adjusting multiple predictors. elevated among members who reported first-degree relative (multivariable-adjusted rate ratio (RR) = 1.91, 95% confidence interval (CI) 1.22-2.99). Early age (< 46 years) further increased developing (sister: multivariable-adjusted RR 3.36, CI 1.62-6.98; mother: 2.35, 1.02-5.43). Bilateral mothers also more two half-fold increase 2.55, 1.02-6.35). did not vary substantially according cancer. age-adjusted development endometrial 2.13 (95% 1.04-4.35), corresponding 1.69 0.42-6.83). There little evidence relatives or affected risk. Some findings have been previously need replication future studies.