Nuclear organization of the genome and the potential for gene regulation
作者： Peter Fraser , Wendy Bickmore
DOI: 10.1038/NATURE05916
关键词:
摘要: Much work has been published on the cis-regulatory elements that affect gene function locally, as well biochemistry of transcription factors and chromatin- histone-modifying complexes influence expression. However, surprisingly little information is available about how these components are organized within three-dimensional space nucleus. Technological advances now helping to identify spatial relationships interactions genes regulatory in nucleus revealing an unexpectedly extensive network communication between chromosomes. A crucial unresolved issue extent which this organization affects function, rather than just reflecting it.
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Wendy A. Bickmore, Peter Teague, Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population Chromosome Research. ,vol. 10, pp. 707- 715 ,(2002) , 10.1023/A:1021589031769
Nicolas Sadoni, Daniele Zink, Nascent RNA synthesis in the context of chromatin architecture. Chromosome Research. ,vol. 12, pp. 439- 451 ,(2004) , 10.1023/B:CHRO.0000034739.96307.8D
Rita Abranches, Alison F. Beven, Luis Aragón-Alcaide, Peter J. Shaw, Transcription Sites Are Not Correlated with Chromosome Territories in Wheat Nuclei Journal of Cell Biology. ,vol. 143, pp. 5- 12 ,(1998) , 10.1083/JCB.143.1.5
Kevin Eggan, Kristin Baldwin, Michael Tackett, Joseph Osborne, Joseph Gogos, Andrew Chess, Richard Axel, Rudolf Jaenisch, Mice cloned from olfactory sensory neurons Nature. ,vol. 428, pp. 44- 49 ,(2004) , 10.1038/NATURE02375
Lyubomira Chakalova, Emmanuel Debrand, Jennifer A. Mitchell, Cameron S. Osborne, Peter Fraser, Replication and transcription: Shaping the landscape of the genome Nature Reviews Genetics. ,vol. 6, pp. 669- 677 ,(2005) , 10.1038/NRG1673
Marieke Simonis, Petra Klous, Erik Splinter, Yuri Moshkin, Rob Willemsen, Elzo de Wit, Bas van Steensel, Wouter de Laat, Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nature Genetics. ,vol. 38, pp. 1348- 1354 ,(2006) , 10.1038/NG1896
Thomas Cremer, Marion Cremer, Steffen Dietzel, Stefan Müller, Irina Solovei, Stanislav Fakan, Chromosome territories--a functional nuclear landscape. Current Opinion in Cell Biology. ,vol. 18, pp. 307- 316 ,(2006) , 10.1016/J.CEB.2006.04.007
Nicola L. Mahy, Paul E. Perry, Wendy A. Bickmore, Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH Journal of Cell Biology. ,vol. 159, pp. 753- 763 ,(2002) , 10.1083/JCB.200207115
Christian P. Bacher, Michèle Guggiari, Benedikt Brors, Sandrine Augui, Philippe Clerc, Philip Avner, Roland Eils, Edith Heard, Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature Cell Biology. ,vol. 8, pp. 293- 299 ,(2006) , 10.1038/NCB1365
Jonathan R Chubb, Shelagh Boyle, Paul Perry, Wendy A Bickmore, Chromatin motion is constrained by association with nuclear compartments in human cells. Current Biology. ,vol. 12, pp. 439- 445 ,(2002) , 10.1016/S0960-9822(02)00695-4