Oxidative stress and ischemic myocardial syndromes.

摘要: Oxidative stress is a condition in which reactive oxygen species (ROS) or free radicals, namely O2*(-), H2O2, and *OH, are generated extra- intracellularly exert toxic effects on cells. The heart one of the major organs affected by ROS. Recent evidence suggests that oxidative common denominator many aspects cardiovascular diseases. During myocardial stress, generation ROS enhanced defense mechanisms myocytes altered. sources cardiac could be mitochondrial electron transport chain, nitric oxide synthase (NOS), NADPH oxidase, xanthine lipoxygenase/cyclooxygenase auto-oxidation various substances, particularly catecholamines. In acute infarction (AMI), two distinct types damage occur to heart: ischemic injury reperfusion injury, lead dysfunction ischemia reperfusion, can produced both endothelial cells circulating phagocytes. Ischemia also causes alterations against Some proteins, including heat-shock overexpressed conditions ischemia/reperfusion protect from injury. This article outlines current understanding their role diseases, syndromes. following covered: pathophysiological atherosclerosis, precipitation MI, myocytes, heart, injuries mechanisms.