Phylogenetic, ontogenetic, and pathological aspects of the urine-concentrating mechanism.

摘要: The urine-concentrating mechanism is one of the most fundamental functions avian and mammalian kidneys. This particular function kidneys developed as a system to accumulate NaCl in birds urea mammals. Based on phylogenetic evidence, may have evolved modification renal medulla's accumulating that observed birds. qualitative conversion inner medulla occur during neonatal period. Human several suboptimal features caused by mechanism. composed various functional molecules, including water channels, solute transporters, vasopressin receptors. Abnormalities channels aquaporin (AQP)1 AQP2, well receptor V2R, are known cause nephrogenic diabetes insipidus. An analysis pathological involved insipidus suggests molecular chaperones improve intracellular trafficking AQP2 and, near future, such become new clinical tool for treating