pH-Dependent photoluminescence "switch-on" nanosensors composed of silver nanoparticles and nitrogen and sulphur co-doped carbon dots for discriminative detection of biothiols.

摘要: Very close structure and property similarities among biothiols, such as glutathione (GSH), cysteine (Cys), homocysteine (Hcy), present a major challenge to achieve their discriminative detection. In this contribution, nanomaterial surface energy transfer (NSET) system was established discriminate GSH from Cys Hcy with the photoluminescence (PL) “switch-on” response. The nanosensor constructed using nitrogen sulphur co-doped carbon dots (N,S-CDs) silver nanoparticles (AgNPs) through assembling an transfer-based quenching system, featuring pH-promoted distinct PL Under neutral conditions, only can encapsulate AgNPs, leaving little chance for N,S-CD binding on of which lead signal recovery, total quantity be determined. However, at pH 3.0 all three kinds biothiols recovery GSH, Cys, determined, due similar slopes intercepts calibration curves. Thus, concentration could further calculated strategy successfully applied detection in human serum, demonstrating its potential bioanalysis significance addressing biological medicinal requirements.