Expression of a retrovirus encoding human HPRT in mice
作者： A. Miller , R. Eckner , D. Jolly , T Friedmann , I. Verma
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摘要: Transmissible retroviruses encoding human hypoxanthine phosphoribosyltransferase (HPRT) were used to infect mouse bone marrow cells in vitro, and the infected transplanted into mice. Both active HPRT-protein chronic HPRT-virus production detected hematopoietic tissue of mice, showing transfer gene. These results indicate possible use for somatic cell therapy.
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