Alectinib induces marked red cell spheroacanthocytosis in a near-ubiquitous fashion and is associated with reduced eosin-5-maleimide binding
作者： Benjamin Solomon , Benjamin Solomon , David Westerman , David Westerman , Janine Campbell
DOI: 10.1016/J.PATHOL.2020.10.023
关键词:
摘要: Summary We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic lymphoma kinase (ALK) which is considered standard first-line treatment ALK-rearranged advanced non-small cell lung cancer. Ninety-five percent developed marked acanthocytosis, echinocytosis and/or spheroacanthocytosis, not observable prior other ALK-inhibitors. Anaemia in 73% (38%
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