Increased ventral striatal monoaminergic innervation in Tourette syndrome.

摘要: Background: Excessive striatal dopaminergic innervation is suggested to underlie Tourette syndrome (TS). Prior imaging and postmortem studies yield conflicting data. Methods: The authors used PET with the type 2 vesicular monoamine transporter ligand [ 11 C]dihydrotetrabenazine (DTBZ) quantify monoaminergic in patients TS (n = 19) control subjects 27). Compartmental modeling was determine blood brain transport (K 1 ) tissue plasma distribution volume (a measure of binding) during continuous infusion DTBZ. data were compared using predefined regions interest on a voxel by basis. Results: There no significant differences binding or between dorsal striatum. With analysis, there increased DTBZ right ventral Conclusions: Previously reported dopamine terminal markers may reflect medication-induced regulation marker expression be result intrinsic synaptic function. Increased suggests that abnormal tics.