Improving molecular radiotherapy dosimetry using anthropomorphic calibration

摘要: Abstract The optimised delivery of Molecular Radiotherapy requires individualised calculation absorbed dose to both targeted lesions and neighbouring healthy tissue. To achieve this, accurate quantification the activity distribution in patient by external detection is vital. Methods This work extends specific anatomy-related calibration true organ shapes. A set patient-specific 3D printed inserts based on a diagnostic CT scan was produced, comprising liver, spleen kidneys. were used calculate factors for 177Lu. These compared with previously reported corresponding models Cristy Eckerman phantom series comparably sized sphere. Monte Carlo calculations radiation performed comparison current clinical dosimetry methods these data. Results Patient-specific are shown be dependent volume, shape position containing impact patient. morphology calculated reduced when dominant contributor beta particles. due small range particles Overestimations recovered hence up 135% observed. Conclusion For accounting size, must used. Such vital if accurate, achieved.