Protein phosphatases come of age.

摘要: The level of phosphorylation any protein depends on the relative activities kinases and phosphatases (1), but latter enzymes have received far less attention, perhaps because difficulty in obtaining a well defined substrate before they can be studied. Nevertheless, information about, serine/threonine has increased enormously over past few years, readers are referred to detailed review (2) for background many primary references. This Minireview will concentrate recent progress that demonstrated key roles these tumor suppression cell division identified novel phosphatase catalytic subunits. Our current understanding structure, specificity, regulation also discussed with emphasis role “targeting subunits.” discovery certain membrane-bound glycoproteins tyrosine is reviewed Ref. 3.