[Control mechanisms of cell transition from the G1 phase to the S phase--the R point].

摘要: The critical moment of regulation when transition the cell from G1 to S phase takes which is decisive for its division so-called R-point (restriction point). disorder molecular mechanisms controlling passage through this site an associated manifestation most tumourous processes. A considerable part mechanism RB protein, binding transcription factors needed activation genes effective in phase. Its capacity depends on extent phosphorylation and activity appropriate kinases their inhibitors.