Presentation of treatment effect in glioblastoma after dose-escalation radiation therapy.

摘要: Glioblastoma is the most aggressive primary brain tumor in adults. Limited treatment options and intense nature of therapy make determining appropriate course for each patient difficult. The appearance transient worsening imaging findings, known as effect, after chemoradiation further complicates clinical decision-making. Accurately differentiating effects from true progression critical subsequent decisions are based largely on radiographic evidence progression. As can cause it possible that use new treatments modified regimens may alter presentation effect. Therefore, physicians should be aware atypical presentations occur, more likely, when modified. Here, we present case a with isocitrate dehydrogenase 1 wild type, O-6-methylguanine-DNA methyltransferase-methylated glioblastoma who underwent dose-escalation radiation (to 75 Gy) exhibited worsened findings at 8 months post-radiation.