Naturally occurring selenium compounds in cancer chemoprevention trials: a workshop summary.

摘要: Evidence from epidemiological studies and a human intervention trial indicates that selenium (Se) may have chemopreventive activity in humans. This report summarizes workshop held by the National Cancer Institute to address use of naturally occurring Se compounds future cancer chemoprevention trials. Differences metabolism inorganic organic can be seen both biochemical handling these forms their kinetics Long-term supplementation could result greater increases muscle stores for rather than forms. Because long half-lives, trials duration assess efficacy safety. The optimal size dose is controversial with respect In China, selenosis was observed some individuals sustained intake at least 750 micrograms/day but not among others intakes exceeding 1 mg. These levels exceed reference dose, measure maximal safe intake, which 350 micrograms/day. A large-scale United States suggests no harm due long-term more 200 deficiency has been shown deleterious effects on immune system, allowing, example, benign form Coxsackievirus become virulent mice. recent results provide an explanation earlier findings showing protective effect elevated against mouse mammary tumor virus. Additional as agent man seem warranted.