An Analysis of Estrogen Metabolism and Breast Cancer Risk

摘要: Breast cancer is the most common noncutaneous form of among women in US. In recent years, overall mortality rate has declined, yet there still exists a significant racial disparity incidence and between African American Caucasian women. While numerous hypotheses have been proposed to explain this difference, few offer biological explanation.There well established association estrogens breast risk, ratio two estrogen metabolites, 2-hydroxyestrone (2OHE1) 16a-hydroxyestrone (16OHE1), implicated as marker risk. Many studies also assessed relationship endogenous mammographic density. Mammographic density one strongest predictors but mechanism by which it influences risk remains unknown. Nonetheless, examined relation 2OHE1:16OHE1 metabolite (EMR).Research suggests that Cytochrome P450 1B1 (CYP1B1) gene may mediate very active metabolism. fact, Leu432Val polymorphism reportedly associated with urinary levels EMR.The objective study was investigate some relationships found 2OHE1: 16OHE1 EMR, CYP1B1 polymorphism, density, race, The EMR both yet, no observed. This if alters does so through variations EMR. When taking race into account, culture, evidence suggest influenced subcellular effects or other intrinsic factors (i.e. genetic variation), passage number only contributor results great public health significance, provides better understanding factors, including differences, etiology cancer, will ultimately lead prevention treatment for all