miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2.
作者： Longlong He , Lifan Liao , Liangzhi Du
关键词:
摘要: Accumulating evidence demonstrates that microRNAs (miRNAs or miRs) play important roles in the development and progression of human malignancies, including oral squamous cell carcinoma (OSCC); however, unique miRNAs are not yet fully understood OSCC. The present study aimed to identify novel associated with OSCC elucidate their functions. Based on a microarray analysis, miR‑144‑3p was found be one most significantly downregulated tissues. Its low expression closely tumor size, differentiation lymph node metastasis. Functionally, overexpression suppressed proliferation, promoted apoptosis, invasion migration cells. In addition, enhancer zeste homolog 2 (EZH2), well‑known oncogene, proven direct target miR‑144‑3p, its protein negatively regulated by miR‑144‑3p. Moreover, EZH2 increased, inversely correlated level Notably, knockdown inhibited cells, whereas partially reversed anticancer effects mediated overexpression. On whole, findings suggest functions as suppressor targeting may thus considered potential diagnostic therapeutic for
sci-hub.st 参考文章(50)
Hae-Yun Jung, Sohee Jun, Moonsup Lee, Han-Cheon Kim, Xin Wang, Hong Ji, Pierre D. McCrea, Jae-Il Park, PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation Molecular Cell. ,vol. 52, pp. 193- 205 ,(2013) , 10.1016/J.MOLCEL.2013.08.028
Sonya Parpart, Xin Wei Wang, microRNA Regulation and Its Consequences in Cancer Current Pathobiology Reports. ,vol. 1, pp. 71- 79 ,(2013) , 10.1007/S40139-012-0002-7
Yong Wang, Yajing Chen, Hua Geng, Can Qi, Yunde Liu, Dan Yue, Overexpression of YB1 and EZH2 are associated with cancer metastasis and poor prognosis in renal cell carcinomas Tumor Biology. ,vol. 36, pp. 7159- 7166 ,(2015) , 10.1007/S13277-015-3417-Z
Saman Warnakulasuriya, Global epidemiology of oral and oropharyngeal cancer Oral Oncology. ,vol. 45, pp. 309- 316 ,(2009) , 10.1016/J.ORALONCOLOGY.2008.06.002
Tongbin Li, William C.S. Cho, MicroRNAs: Mechanisms, Functions and Progress Genomics, Proteomics & Bioinformatics. ,vol. 10, pp. 237- 238 ,(2012) , 10.1016/J.GPB.2012.10.002
Yasuko Matsukawa, Shuho Semba, Hirotaka Kato, Akihiko Ito, Kazuyoshi Yanagihara, Hiroshi Yokozaki, Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer Cancer Science. ,vol. 97, pp. 484- 491 ,(2006) , 10.1111/J.1349-7006.2006.00203.X
T Sasahira, M Kurihara, U K Bhawal, N Ueda, T Shimomoto, K Yamamoto, T Kirita, H Kuniyasu, Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer British Journal of Cancer. ,vol. 107, pp. 700- 706 ,(2012) , 10.1038/BJC.2012.330
Lingbo Zhao, Yang Yu, Jie Wu, Jing Bai, Yuzhen Zhao, Chunming Li, Wenjing Sun, Xiumei Wang, Role of EZH2 in oral squamous cell carcinoma carcinogenesis. Gene. ,vol. 537, pp. 197- 202 ,(2014) , 10.1016/J.GENE.2014.01.006
Yuan Shao, Yiping Qu, Siwen Dang, Bowen Yao, Meiju Ji, MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6 Cancer Cell International. ,vol. 13, pp. 51- 51 ,(2013) , 10.1186/1475-2867-13-51
Kenneth J. Livak, Thomas D. Schmittgen, ANALYSIS OF RELATIVE GENE EXPRESSION DATA USING REAL-TIME QUANTITATIVE PCR AND THE 2(-DELTA DELTA C(T)) METHOD Methods. ,vol. 25, pp. 402- 408 ,(2001) , 10.1006/METH.2001.1262