Importance of sulfate, cysteine and methionine as precursors to felinine synthesis by domestic cats (Felis catus).

摘要: There is conflicting evidence in the literature on utilization of cysteine and methionine as precursors to urinary sulfur-containing amino acid felinine cats. Three entire domestic short-haired male cats, housed individually metabolism cages, were injected intraperitoneally with either [35S]-sulfate, [35S]-cysteine, or [35S]-methionine. Daily urine samples collected quantitatively for up 9 days after injection. Each cat was once each compound observing an appropriate interval [35S] be depleted between injections. All analysed content total radioactivity. Felinine isolated from sample No radioactivity found cats [35S]-sulfate. The mean (+/-S.E.M.) cumulative recovery [35S]-sulfate 90.6+/-6.1% 4 days. incorporation rate into by receiving [35S]-cysteine [35S]-methionine 11.6+/-1.6 8.6+/-0.6%, respectively, recoveries 58.1+/-3.7 36.0+/-8.0%, respectively. Cysteine methionine, but not sulfate, are felinine, being a more important precursor compared methionine.