Killing cancer cells by poly-drug elevation of ceramide levels
作者： Norman S. Radin
DOI: 10.1046/J.1432-1033.2001.01845.X
关键词:
摘要: Many papers have shown that sphingolipids control the balance in cells between growth and proliferation, cell death by apoptosis. Sphingosine-1-phosphate (Sph1P) glucosylceramide (GlcCer) induce proliferation processes, ceramide (Cer), a metabolic intermediate two, induces In cancers, seems to come undone it should be possible kill enhancing processes lead accumulation. The two systems are intertwined, modulated variety of agents affecting activities enzymes Cer-GlcCer-Sph1P interdependence. It is proposed successful cancer chemotherapy requires use many elevate levels adequately. This review updates current knowledge sphingolipid metabolism some evidence showing plays causal role apoptosis induction, as well chemotherapeutic agent.
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sci-hub.se 参考文章(107)
Maria Grazia Cifone, Graziella Migliorati, Raffaella Parroni, Cristina Marchetti, Danilo Millimaggi, Angela Santoni, Carlo Riccardi, Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood. ,vol. 93, pp. 2282- 2296 ,(1999) , 10.1182/BLOOD.V93.7.2282
René J Raggers, Thomas Pomorski, Joost CM Holthuis, Nanette Kälin, Gerrit van Meer, None, Lipid traffic: the ABC of transbilayer movement Traffic. ,vol. 1, pp. 226- 234 ,(2000) , 10.1034/J.1600-0854.2000.010305.X
J.J. Schroeder, H.M. Crane, J. Xia, D.C. Liotta, A.H. Merrill, Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. Journal of Biological Chemistry. ,vol. 269, pp. 3475- 3481 ,(1994) , 10.1016/S0021-9258(17)41887-4
Pierre Morell, Norman S. Radin, Specificity in Ceramide Biosynthesis from Long Chain Bases and Various Fatty Acyl Coenzyme A's by Brain Microsomes Journal of Biological Chemistry. ,vol. 245, pp. 342- 350 ,(1970) , 10.1016/S0021-9258(18)63398-8
J.C. Strum, G.W. Small, S.B. Pauig, L.W. Daniel, 1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. Journal of Biological Chemistry. ,vol. 269, pp. 15493- 15497 ,(1994) , 10.1016/S0021-9258(17)40706-X
Armando E. Giuliano, Tie-Yan Han, Myles C. Cabot, Yong-Yu Liu, SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells. Cancer Research. ,vol. 59, pp. 880- 885 ,(1999)
T. Goldkorn, K.A. Dressler, J. Muindi, N.S. Radin, J. Mendelsohn, D. Menaldino, D. Liotta, R.N. Kolesnick, Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells: Evidence that ceramide may mediate sphingosine action Journal of Biological Chemistry. ,vol. 266, pp. 16092- 16097 ,(1991) , 10.1016/S0021-9258(18)98520-0
Christine Bezombes, Nicolas Maestre, Guy Laurent, Thierry Levade, Ali Bettaïeb, Jean-Pierre Jaffrézou, Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833 The FASEB Journal. ,vol. 12, pp. 101- 109 ,(1998) , 10.1096/FASEBJ.12.1.101
Jean‐Pierre Jaffrezou, Nicolas Maestre, Veronique Mas‐Mansat, Christine Bezombes, Thierry Levade, Guy Laurent, Positive feedback control of neutral sphingomyelinase activity by ceramide The FASEB Journal. ,vol. 12, pp. 999- 1006 ,(1998) , 10.1096/FASEBJ.12.11.999
Adriana Haimovitz-Friedman, Richard Kolesnick, Margaret White-Jones, Mark Garzotto, Zvi Fuks, Desiree Ehleiter, Wen Chieh Liao, Youwei Jiang, 12-O-Tetradecanoylphorbol-13-acetate-induced Apoptosis in LNCaP Cells Is Mediated through Ceramide Synthase Cancer Research. ,vol. 58, pp. 2260- 2264 ,(1998)