Biologically active proteins activatable by peptidase

摘要: The present invention provides biologically active proteins that are activatable by peptidase exposure, such as dipeptidase exposure. protein may be a recombinant version of factor is processed from native precursor molecule in vivo. Upon administration the product to patient need, converted form body endogenous dipeptidase. design products simplifies manufacturing process, and provide for additional therapeutic benefits improved pharmacokinetics, half-life, and/or safety profile. further methods treatment with compounds, well production manufacture.