Effects of potential aneuploidy inducing agents on microtubule assembly in vitro
作者： Margareta Wallin , Beryl Hartley-Asp
DOI: 10.1016/0027-5107(93)90141-2
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摘要: Abstract The present study was carried out with the 10 known or suspected spindle poisons of Commission European Communities program to aneuploidy induction. We have investigated these substance assembly isolated bovine microtubules at 10, 100 and 1000 μM studied morphology by electron microscopy. substances could be grouped into two categories, strong weak inhibitors. Colchicine, vinblastine thiomerosal were inhibitors; cadmium chloride, thiabendazole, chloral hydrate, hydroquinone, diazepam econazole inhibitors, latter three causing aberrant forms visible on Pyrimethamine did not inhibit microtubules, but produced forms.
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