Successful Treatment of Acquired Hemophilia A With Rituximab and Steroids in a 5-Year-Old Girl

作者: Matthew Fletcher , Ofelia Crombet , Jaime Morales-Arias

DOI: 10.1097/MPH.0B013E318286D536

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摘要: Acquired hemophilia A is a very rare, serious bleeding disorder. We describe 5-year-old female who developed an acquired factor VIII inhibitor, and while under treatment with steroids, had intestinal perforation peritonitis septic shock, making her poor candidate for further immunosuppression. She was treated rituximab rapid, complete eradication of the inhibitor. represents first published case pediatric patient successfully rituximab.

参考文章(6)
Thomas F. Gregory, Barry Cooper, Case report of an acquired factor XIII inhibitor: diagnosis and management. Proceedings (Baylor University. Medical Center). ,vol. 19, pp. 221- 223 ,(2006) , 10.1080/08998280.2006.11928166
Massimo Franchini, Marco Zaffanello, Giuseppe Lippi, Acquired hemophilia in pediatrics: a systematic review. Pediatric Blood & Cancer. ,vol. 55, pp. 606- 611 ,(2010) , 10.1002/PBC.22657
R. J. MORACA, M. V. RAGNI, Acquired anti-FVIII inhibitors in children. Haemophilia. ,vol. 8, pp. 28- 32 ,(2002) , 10.1046/J.1365-2516.2002.00574.X
Massimo Franchini, Rituximab in the treatment of adult acquired hemophilia A: A systematic review Critical Reviews in Oncology Hematology. ,vol. 63, pp. 47- 52 ,(2007) , 10.1016/J.CRITREVONC.2006.11.004