Enantioselective Direct Bisvinylogous 1,6-Additions of β-Allyl-2-cyclohexenone to α,α-Dicyanodienes through Trienamine Catalysis
作者： Xin Feng , Zhi Zhou , Xiang Yin , Rui Li , Ying-Chun Chen
关键词:
摘要: An asymmetric direct ϵ-regioselective bisvinylogous 1,6-addition reaction of β-allyl-2-cyclohexenone to β-substituted α,α-dicyanodienes was developed through trienamine catalysis a bifunctional primary amine–thiourea compound. Excellent enantioselectivity (up 97 % ee) obtained even such remote mode. In addition, more complex cyclic frameworks could be efficiently constructed with high stereoselectivity.
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