hnRNP E1 at the crossroads of translational regulation of epithelial-mesenchymal transition.

摘要: The epithelial-mesenchymal transition (EMT), in which cells undergo a switch from polarized, epithelial phenotype to highly motile fibroblastic or mesenchymal is fundamental during embryonic development and can be reactivated variety of diseases including cancer. Spatio-temporally-regulated mechanisms are constantly orchestrated allow adapt their changing environments when disseminating distant organs. Although numerous transcriptional regulatory factors currently well-characterized, the post-transcriptional control EMT requires continued investigation. hnRNP E1 protein displays major role tumor cell plasticity by regulating translatome through multiple non-redundant mechanisms, this exemplified absent. binding RNA molecules leads direct indirect translational regulation specific sets proteins: (1) targets has translation preventing elongation translation; (2) E1-dependent alternative splicing prevent generation competing long non-coding that acts as decoy for microRNAs (miRNAs) involved inhibition master regulators; (3) 3' untranslated region transcripts also positively regulate stability certain mRNAs improve translation. Globally, appears proteome reprogramming plasticity, either