Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States
作者： Kelly Virecoulon Giudici , Joseph M. Kindler , Berdine R. Martin , Emma M. Laing , George P. McCabe
DOI: 10.1186/S12986-017-0171-9
关键词:
摘要: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years. was a cross-sectional analysis of baseline data from 161 boys 157 girls (ages years) who previously participated double-blinded randomized placebo controlled trial vitamin D supplementation. Relationships fasting serum total osteocalcin (tOC), undercarboxylated (ucOC), leptin, were analyzed. Approximately 52% participants obese based on percent body fat cutoffs (>25% for >32% girls) about 5% had glucose within prediabetic range (i.e. 100 125 mg/dL). Serum tOC not correlated with glucose, insulin, HOMA-IR, or HOMA-β after adjusting fat. However, ucOC negatively (partial r = −0.16; p = 0.04) adjustment Leptin positive predictor age, sex (all p < 0.001). These depict an inverse relationship between various children. notion that link energy metabolism healthy supported. NCT00931580 .
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