Fabrication of three dimensional polymeric scaffolds with spherical pores

摘要: This paper reports polymeric scaffolds with spherical internal macropores and relatively large external dimension. Paraffin spheres the diameter of several hundred microns were prepared by a suspension technique. Particulate leaching technique based on this kind porogens was combined room-temperature compression molding to fabricate biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) porous potentially for tissue engineering or in situ induction. The exhibited ordered good pore interconnectivity. porosity ranged from 80 97% adjusted simply varying porogen content. foams around 90% have compressive modulus over 3 MPa strength 0.2 MPa. As preliminary cell experiments 3T3 fibroblasts cultured indicate, processing procedure has not brought problem cytotoxicity.