Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors.
作者： X. Pan , A. Luhrmann , A. Satoh , M. A. Laskowski-Arce , C. R. Roy
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摘要: Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV system large number different bacterial containing ankyrin repeat homology domains called Anks. The L. AnkX protein prevented microtubule-dependent vesicular transport interfere with fusion pneumophila-containing vacuole late endosomes after infection macrophages, which demonstrates Ank have functions important for cells.
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