DOI: 10.1016/J.YFRNE.2014.09.003
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摘要: The avian song control system provides an excellent model for studying transsynaptic trophic effects of steroid sex hormones. Seasonal changes in systemic testosterone (T) and its metabolites regulate plasticity this system. Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes nucleus HVC adult birds, including addition newborn neurons. This interaction may also occur transsynpatically; T increases synthesis BDNF HVC, protein is then released by neurons on postsynaptic cells RA where it has activity morphology. Androgen action their a retrograde effect new HVC. functional linkage steroids be adaptive value regulating coordinating circuit function reproductively relevant contexts.