Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.

作者: Eliot A. Brenowitz

DOI: 10.1016/J.YFRNE.2014.09.003

关键词:

摘要: The avian song control system provides an excellent model for studying transsynaptic trophic effects of steroid sex hormones. Seasonal changes in systemic testosterone (T) and its metabolites regulate plasticity this system. Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes nucleus HVC adult birds, including addition newborn neurons. This interaction may also occur transsynpatically; T increases synthesis BDNF HVC, protein is then released by neurons on postsynaptic cells RA where it has activity morphology. Androgen action their a retrograde effect new HVC. functional linkage steroids be adaptive value regulating coordinating circuit function reproductively relevant contexts.

参考文章(103)
Kiran K. Soma, Vesta N. Hartman, John C. Wingfield, Eliot A. Brenowitz, Seasonal changes in androgen receptor immunoreactivity in the song nucleus HVc of a wild bird. The Journal of Comparative Neurology. ,vol. 409, pp. 224- 236 ,(1999) , 10.1002/(SICI)1096-9861(19990628)409:2<224::AID-CNE4>3.0.CO;2-V
Constance Scharff, John R Kirn, Matthew Grossman, Jeffrey D Macklis, Fernando Nottebohm, None, Targeted neuronal death affects neuronal replacement and vocal behavior in adult songbirds. Neuron. ,vol. 25, pp. 481- 492 ,(2000) , 10.1016/S0896-6273(00)80910-1
Citlali Trueta, Francisco F. De-Miguel, Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system. Frontiers in Physiology. ,vol. 3, pp. 319- 319 ,(2012) , 10.3389/FPHYS.2012.00319
C. L. Pytte, S. George, S. Korman, E. David, D. Bogdan, J. R. Kirn, Adult Neurogenesis Is Associated with the Maintenance of a Stereotyped, Learned Motor Behavior The Journal of Neuroscience. ,vol. 32, pp. 7052- 7057 ,(2012) , 10.1523/JNEUROSCI.5385-11.2012
Yan Zhang, Omar Tounekti, Beverly Akerman, Cynthia G. Goodyer, Andréa LeBlanc, 17-β-Estradiol Induces an Inhibitor of Active Caspases The Journal of Neuroscience. ,vol. 21, ,(2001) , 10.1523/JNEUROSCI.21-20-J0007.2001
B. A. Alward, J. Balthazart, G. F. Ball, Differential effects of global versus local testosterone on singing behavior and its underlying neural substrate Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 19573- 19578 ,(2013) , 10.1073/PNAS.1311371110
Alistair Dawson, Verdun M. King, George E. Bentley, Gregory F. Ball, Photoperiodic Control of Seasonality in Birds Journal of Biological Rhythms. ,vol. 16, pp. 365- 380 ,(2001) , 10.1177/074873001129002079
John Meitzen, David J. Perkel, Eliot A. Brenowitz, Seasonal changes in intrinsic electrophysiological activity of song control neurons in wild song sparrows Journal of Comparative Physiology A. ,vol. 193, pp. 677- 683 ,(2007) , 10.1007/S00359-007-0222-1
Kiran K. Soma, Barney A. Schlinger, John C. Wingfield, Colin J. Saldanha, Brain aromatase, 5α‐reductase, and 5β‐reductase change seasonally in wild male song sparrows: Relationship to aggressive and sexual behavior Journal of Neurobiology. ,vol. 56, pp. 209- 221 ,(2003) , 10.1002/NEU.10225
E.N. Ottem, D.J. Bailey, C.L. Jordan, S. Marc Breedlove, With a little help from my friends: androgens tap BDNF signaling pathways to alter neural circuits. Neuroscience. ,vol. 239, pp. 124- 138 ,(2013) , 10.1016/J.NEUROSCIENCE.2012.12.019