Some interrelations of neutrophil chemotaxis, lysosomal enzyme secretion, and phagocytosis as revealed by synthetic peptides.

摘要: Synthetic oligopeptides of appropriate structure stimulate neutrophil random locomotion, chemotaxis, lysosomal enzyme secretion, and phagocytosis. The structure-activity relationships found for enhanced migration secretion strongly suggest that the peptides bind to a structurally specific receptor on surface. It is further suggested binding peptide same initiates all these functions. postulated this accomplished by receptor-peptide combination initiating series parallel but coordinated interdependent biochemical sequences leading either microfilament or microtubule activation in addition other processes. various functions differentially utilize systems.