Saccharin/cyclamates: epidemiological evidence.

摘要: Adequate data on the carcinogenicity of saccharin and cyclamate to humans are available only for urinary bladder. In studies available, exposure cannot be distinguished readily. Descriptive have shown no evidence time trends in bladder cancer that can related use or cyclamate. Likewise, diabetics, who used more than other people, an increased risk cancer. This association, however, is probably confounded negatively by cigarette smoking. Thirteen case-control addressed relationship intake individuals. While statistically significant positive associations been observed, a similar number negative has also observed. Studies dose-response relationships consistent pattern. with smoking habits interaction heavy smoking, as might expected from promotional effect. some studies, observed female non-smokers--a group otherwise at low