Immune deficiency and risk for malignancy among persons with AIDS.
作者： Sam M. Mbulaiteye , Robert J. Biggar , James J. Goedert , Eric A. Engels
DOI: 10.1097/00126334-200304150-00010
关键词:
摘要: Background: People with AIDS have an elevated risk for cancer. We studied the relationship between cancer and AIDS-related immunosuppression as measured by CD4 count at onset. Methods: linked records from registries in 11 US regions (1990-1996). 82,217 (86.6%) adults who had a onset survived into follow-up period. calculated standardized incidence ratios (SIRs) AIDS-defining (Kaposi sarcoma [KS], non-Hodgkin lymphoma [NHL] cervical cancer) well non-AIDS-defining cancers 2 years after For each cancer, change SIRs across counts (0-49 cells/mm 3 , 50-99 100-199 ≥200 ) was modeled using Poisson regression. Results: The KS, NHL, were 258, 78, 8.8, respectively. fall of 100 RRs 1.36 (95% CI: 1.29-1.43) KS 1.48 1.37-1.59) NHL. Among NHL subtypes, association lower strongest immunoblastic (RR = 1.64, 95% 1.37-1.96, per decline central nervous system 2.29, 1.95-2.69). SIR did not vary (p =.74). (overall 2.1), neither combined nor specific types associated declining counts. Conclusions: increased level Risks other cancers, including unrelated to Elevated risks non-AIDS may be result lifestyle factors.
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