A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6‑mercaptopurine.

摘要: Abstract The clinical applications of anticancer drugs are restricted due to the incomplete delivery cancerous tissue and numerous drug resistance mechanisms involved in malignant cells. In this regard, stimuli-responsive nanomaterials offer a promising prospect deal with these concerns. present study, ternary responsive hybrid gold/nanogels (Au/NGs) were synthesized as new nanoplatform simultaneously carry two drugs, i.e., doxorubicin (DOX) 6-mercaptopurine (MP). For purpose, successfully loaded (the loading capacity 23% 11%, respectively) into Au/NGs by electrostatic interaction Au S bonds triggered release ability was assessed comparing environments simulated physiological tumor tissue. incorporation disulfide bond linkers, pH sensitive, thermosensitive polymeric segments endowed NGs an excellent property reducing acidic hyperthermia environments, which greatly facilitates Intracellular tracking DOX@MP-Au/NGs confirmed efficient accumulation cellular uptake developed cytotoxicity studies showed pronounced inhibition compared free DOX@MP. It concluded that ternary-responsive have great potential for co-delivery DOX MP can be used cancer therapy.