Joining the dots: Production, processing and targeting of U snRNP to nuclear bodies
作者： Debra J. Shaw , Paul Eggleton , Philip J. Young
DOI: 10.1016/J.BBAMCR.2008.07.025
关键词:
摘要: The spliceosome is the RNP complex than catalyses removal of introns from Uridine-rich small nuclear ribonucleoproteins (U snRNPs) that make up main components this complex. production these RNPs an intricate process, involving several key stages. These include: 1) transcription U snRNAs; 2) their export; 3) cytoplasmic assembly snRNP; 4) import; 5) processing within Cajal bodies and nucleolus; 6) storage in interchromatin granule clusters (IGCs). This review focuses on each stages, discussing complexes involved as well trafficking targeting mechanisms involved.
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