Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis

摘要: We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives. This process is enabled the merger aerobic oxidative Cu catalysis enolate interception reminiscent malonyl-CoA reactivity in polyketide biosynthesis. method enables synthesis monoaryl acetate derivatives containing electrophilic functional groups that are incompatible existing paradigms. The utility reaction demonstrated drug intermediate and late-stage functionalization.