Naphthenic Acid Mixtures from Oil Sands Process-Affected Water Enhance Differentiation of Mouse Embryonic Stem Cells and Affect Development of the Heart.
作者： Paria Mohseni , Noah A. Hahn , Richard A. Frank , L. Mark Hewitt , Mehrdad Hajibabaei
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摘要: Extraction of petrochemicals from the surface mining oil sand deposits results in generation large volumes sands process-affected water (OSPW). Naphthenic acids (NA) are generally considered to be among most toxic components OSPW. Previous studies have shown that NAs aquatic organisms, however knowledge their effects on mammalian health and development is limited. In present study, we evaluated developmental an NA extract prepared fresh OSPW differentiating mouse embryonic stem cells (ESC). We found treatment with at noncytotoxic concentrations alters expression various lineage specification markers heart. Notably, cardiac specific such as Nkx2.5, Gata4, Mef2c were significantly up-regulated. Moreover, exposure enhanced differentiation embryoid bodies resulted early appearance spontaneously beating clusters. Inter...
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