Beware of the content!-exosomes as benefactors and agitators.

摘要: This editorial refers to ‘Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice’ by J.M. Aliotta et al ., pp. 319–330. Exosomes form part of the extracellular vesicle (EV) pool, consisting different cell-derived structures generated from cytoplasmic membrane components their source cells. Exosomes are small vesicles (30–100 nm) can be released multi-vesicular bodies spontaneously or response external signals, such as mechanic chemical stimuli. Exosomes, like other EV, act inter-cellular messengers delivering RNA species (e.g. miRNA) proteins remote organs cells.1 Accordingly, exosomes influence multiple biological processes immune responses2,3 tumour growth4 consequently have gained much attention therapeutic targets. However, one must not blind sighted potential beneficial effects. In this issue Cardiovascular Research , co-workers5 extended previous work on (PAH) mice now pinpointing culprit EV fraction when inducing PAH injection derived monocrotaline (MCT)-treated mice.6 Infusion exosome …