Neurocognitive subtypes of chronic schizophrenia

摘要: Performance on four key neurocognitive tasks was used to search for subtypes in 104 DSM-IIIR schizophrenic patients. The were the Wisconsin Card Sorting Test index executive prefrontal cerebral function, intrusion errors from California Verbal Learning tap hippocampal-diencephalic mnestic bilateral hand performance Purdue Pegboard fine motor-basal ganglial and a pro-rated IQ Wechsler Adult Intelligence Scale-Revised measure general cognitive-cerebral function. Neurocognitive data analyzed using hierarchical disjoint clustering procedures with Euclidean distance. A five cluster solution considered optimal. Cluster 1 (n = 24) comprised patients selective executive-prefrontal dysfunction; 2 16) suggested normative function; 3 20) involved executive-motor/cortico-basal deficit; 4 25) dementia/multi-focal disturbance; 5 19) consisted of deficit. differed significantly age, duration illness, extent hospitalization. Suggestive trends sex composition anti-Parkinsonian medication patterns noted. combined analysis have promise reducing clarifying heterogeneity schizophrenia.